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desmopressin bedwetting “This new relationship requires practical cooperation to deliver concrete results,” Biden said. “The thing that has impressed me from the beginning, and I said this to the president early on, and he’s concluded as well, is that you are candid, you are constructive. Developing this new relationship, both qualities are sorely needed. Candor generates trust, and trust is the basis on which real change, constructive change, is made.”